The Human Early-Life Exposome (HELIX) project is multi-center research project that aims to characterize early-life environmental exposures and associate these with omics biomarkers and child health outcomes (Vrijheid, 2014. doi: 10.1289/ehp.1307204). We used a subset of HELIX data from Exposome Data Challenge 2021 (hold by ISGlobal) as an example to illustrate LUCID model.
Format
A list with 4 matrices corresponding to exposures (G), omics data (Z), outcome (Y) and covariates (CoY)
- exposure
8 exposures to environmental pollutants. Variables end with m represent maternal exposures; end with c represent children exposures
- omics
10 proteins
- outcome
A continuous outcome for BMI-z score based on WHO standard, A binary outcome for body mass index categories at 6-11 years old based on WHO reference (0: Thinness or Normal; 1: Overweight or Obese)
- covariate
3 covariates including mother's bmi, child sex, maternal age